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GIARDIA
Giardiasis is a gastrointestinal (GI) syndrome caused
by multiple species of a flagellated protozoan
parasite that infects many vertebrates including dogs,
cats, and people.
The parasite is found worldwide and has a wide host
range. Giardia exists in the GI tract as a
motile trophozoite or a nonmotile cyst. The trophozoites
live in the upper small intestine of the dog
and are more common in diarrheic stools but are not
environmentally resistant. The cysts, which
are found in the cecum of dogs, are common in both normal
and diarrheic stools, and can survive in
the environment for days to weeks. The cysts are considered
to be immediately infective.
Transmission occurs primarily from exposure to cysts
from fecal-oral contact or exposure to cysts
on fomites (an object that is not in itself harmful,
but is able to harbor pathogenic microorganisms
and thus may serve as an agent of transmission of an
infection, such as food bowls, dog crates,
houses, even an article of clothing) or in contaminated
water. Transmission can also occur from
ingestion of trophozoites in diarrheic stools.
After oral exposure to cysts, gastric and duodenal secretions
trigger the release of trophozoites.
The parasites inhibit host enzymatic actions and cause
rapid sloughing of microvilli cells that line
the intestinal tract. This causes a malabsorption syndrome.
The hosts immune status may help
determine the development of clinical disease. Immunosuppressed
animals develop clinical signs of
Giardiasis much more commonly than normal animals. Remember
stress is immunosuppressive.
Stress occurs in many forms and can be environmental,
pregnancy, etc. Animals housed in groups
are more likely to develop Giardia infections.
Subclinical (no clinical signs) infections are common
and infection may also be self-limiting in
27-35 days. Acute diarrhea that is occasionally watery
is common. Chronic diarrhea may also
occur and appears as greasy semiformed stools, weight
loss or poor weight gain. Vomiting or fever
are uncommon.
Standard fecal flotation procedures are inadequate and
special fecal examination procedures are
required for identification of the parasites.
The treatment of choice is Metronidazole at a dose of
15-30 mg/kg of body weight orally given once
or twice daily. I have heard many reports recently of
Panacur being used with success but I have
no personal experience with this method of treatment.
Resolution of clinical signs usually occurs within 7
days of treatment. Prevention involves boiling or
filtering of water before drinking and disinfection
of contaminated premises with quaternary
ammonium compounds. |